Progesterone Cream

Best For

• Menopause symptoms – learn more about Menopause

• Hormone balance – explore Bioidentical Hormone Replacement Therapy

• PMS relief – see Irregular or Painful Periods

• Mood stabilization – read about Hormone Therapy and Longevity

• Sleep support – visit Insomnia

• Bone health – learn about Estrogen and Bone Density

How Does It Work?

Apply the cream: Use a measured dose on thin-skinned areas with good circulation (inner arms, neck, chest, or upper thighs) as directed. Experience symptom relief: Steady transdermal absorption helps support sleep, calm mood, and overall cycle comfort. Track results: Meet with your clinician to review symptoms and labs, then fine-tune dosing for consistent benefits.

What is a Progesterone Cream?

General information: Progesterone cream is a transdermal form of bioidentical progesterone used to help balance hormones when endogenous levels decline or fluctuate. It is commonly considered for perimenopause and postmenopause when symptoms like sleep disruption, mood changes, or cyclical discomfort appear.
The science: Applied to the skin, bioidentical progesterone is absorbed into the bloodstream without first-pass liver metabolism. Stable levels can support GABAergic calm, sleep quality, and endometrial balance when paired with estrogen where appropriate.

Benefits

• May improve sleep onset and quality

• Can help ease anxious or irritable mood states related to hormonal shifts

• Supports balanced estrogen-progesterone ratio when used with Hormone Replacement Therapy

• Part of a whole-body plan that may include functional medicine, nutrition, movement, and stress care

Ingredients

Active ingredient: bioidentical progesterone in a dermatologically appropriate base. In combination care, clinicians may pair with estradiol or recommend separate local vaginal therapies depending on goals.

Suggested Use

Apply exactly as prescribed, typically once or twice daily. Rotate sites to minimize skin irritation. Use a consistent time of day and dose. Do not exceed recommended amounts without clinician guidance.

Safety Information

Use only under medical supervision. Possible effects can include breast tenderness, drowsiness, or skin irritation. Patients with hormone-sensitive conditions or a history of thromboembolic events require individualized evaluation. If you are using systemic estrogen and have a uterus, adequate progesterone is important for endometrial protection. Coverage varies by plan — see our Insurance & Payments page for benefit verification.

What Our Patients Say

“Adding progesterone cream helped me sleep through the night and eased evening irritability.”
See more testimonials.

Why Aligned Modern Health?

• Personalized dosing based on symptoms, history, and labs

• Bioidentical options with clear education on cream vs pills vs patches

• Root-cause, whole-body support including nutrition, sleep, and stress strategies

• Ongoing monitoring for safety, efficacy, and long-term results

Frequently Asked Questions

What is hormone therapy?
Hormone therapy supports declining or imbalanced hormones using bioidentical estrogen and/or progesterone to reduce symptoms and improve quality of life under clinical oversight.
Is progesterone cream a safe option for me? For many patients, yes when prescribed and monitored. Your clinician will review risks, medications, and history to determine fit and dosing.
What’s the difference between progesterone cream, pills, and patches?

• Cream: transdermal, flexible dosing, avoids first-pass metabolism.

• Pills: systemic, predictable dosing, first-pass liver metabolism.

• Patches (estrogen): often paired with progesterone for endometrial protection if you have a uterus.
  How soon will I feel the results? Some patients notice sleep and mood benefits within 1–3 weeks. Full benefits often develop over several cycles as dosing is optimized.
  Can I shower or swim after applying progesterone cream? Yes, once fully absorbed. Apply to clean, dry skin and allow adequate drying time before bathing or vigorous activity.
  What if I miss a day? Resume your next scheduled dose. Do not double up without clinician guidance.
  Is it safe in the long term? Safety depends on individualized risk, dose, and monitoring. Regular follow-ups help ensure appropriate, effective use.
  Does insurance cover it? Coverage varies by plan and pharmacy. We can help verify benefits at our Insurance & Payments page.
  Can I use progesterone cream alongside other hormone therapy? Yes. Many patients use it with systemic estrogen; your clinician will tailor a coordinated plan and monitor response.

Start Your Progesterone Replacement Therapy Journey

Choose a straightforward, topical path to balanced hormones with physician-guided care. Begin with an evaluation, review your options, and move toward steadier sleep, mood, and daily comfort.
Schedule your consultation